A Brother printer setup issue can occur because of the printer problem. An issue with the operating system can also give rise to printer setup problems. You must find the cause that leads to the printer setup issue and troubleshoot them. A setup problem does not allow the printer to connect with the computer. There can be an issue with the connection, printer driver, hardware, etc. There are several solutions to resolve the Brother printer problem. You may find printer problems in both Windows and the Mac OS.